Skeletal muscle atrophy has extreme adverse consequences. Molecular mechanisms that mediate the process of atrophy are not well defined. Recent studies have focused on diverse molecular cascades that control the activation of ubiquitin ligases, indicating that the involvement of the ubiquitin proteasome may be common to a range of atrophic stimuli.

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Journal Cell
McKinnell, I.W, & Rudnicki, M.A. (Michael A.). (2004). Molecular mechanisms of muscle atrophy. Cell, 119(7), 907–910. doi:10.1016/j.cell.2004.12.007