Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
Adema, C.M. (Coen M.), Hillier, L.W. (LaDeana W.), Jones, C.S. (Catherine S.), Loker, E.S. (Eric S.), Knight, M. (Matty), Minx, P. (Patrick), … Wilson, R.K. (Richard K.). (2017). Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 8. doi:10.1038/ncomms15451