The replacement correction factor (Prepl) in ion chamber dosimetry accounts for the effects of the medium being replaced by the air cavity of the chamber. In TG‐21, Prepl was conceptually separated into two components: fluence correction, Pfl, and gradient correction, Pgr. In TG‐51, for electron beams, the calibration is at dref where Pgr is required for cylindrical chambers and Pfl is unknown and assumed to be the same as that for a beam having the same mean electron energy at dmax. For cylindrical chambers in high‐energy photon beams, Prepl also represents a major uncertainty in current dosimetry protocols. In this study, Prepl is calculated with high precision (<0.1%) by the Monte Carlo method as the ratio of the dose in a phantom to the dose scored in water‐walled cylindrical cavities of various radii (with the center of the cavity being the point of measurement) in both high energy photon and electron beams. It is found that, for electron beams, the mean electron energy at depth is a good beam quality specifier for Pfl; and TG‐51's adoption of Pfl at dmax with the same mean electron energy for use at dref is proven to be accurate. For Farmer chambers in photon beams, there is essentially no beam quality dependence for Prepl values. In a Co photon beam, the calculated Prepl is about 0.4–0.6% higher than the TG‐21 value, indicating TG‐21 (and TG‐51) used incorrect values of Prepl for cylindrical chambers.

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Journal Medical Physics
Wang, L., & Rogers, D.W.O. (2008). Sci‐Fri PM: Planning‐10: The replacement correction factors for cylindrical chambers in megavoltage beams. In Medical Physics (Vol. 35). doi:10.1118/1.2965982