Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice
Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.
|Keywords||Betaine homocysteine s-methyltransferase, Homocysteine, Memory, Morris water maze, MRI, Y-maze|
|Journal||Applied Physiology, Nutrition and Metabolism|
Prieur, E.A.K. (Emily A.K.), Pjetri, E. (Eneda), Zeisel, S.H. (Steven H.), & Jadavji, N.M. (Nafisa M.). (2017). Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Applied Physiology, Nutrition and Metabolism, 42(11), 1228–1231. doi:10.1139/apnm-2017-0182