Gas chromatography analysis of the essential oils of leaves and bark collected from the newly discovered tree Pleodendron costaricense identified α-pinene, β-pinene, β-myrcene, β-thujene, and β-caryophyllene as their major constituents. Phytochemical analysis of P. costaricense parts led to the isolation and identification of δ-tocotrienol, β-sitosterol, four known drimane-type sesquiterpenes, cinnamodial (1), cinnamosmolide (2), polygodial (3), and mukaadial (4), and two new compounds, a drimane-type sesquiterpene, parritadial (5), and an eremophilane-type sesquiterpene, pleodendione (6). Antifungal assays with the two major compounds, 1 and 2, were carried out, and results showed a high activity of 1 against Alternaria alternata (MIC = 3.9 μg/mL), Candida albicans azole-resistant strain D10, and Wangiella dermatitides (MICs = 15.6 μg/mL). Compound 2 showed less potent antifungal activities than 1 but was more effective against Candida albicans azole-resistant strain CN1A (MIC = 23.4 μg/mL) and Pseudallescheria boydii (MIC = 78.1 μg/mL). A combination of the dialdehyde sesquiterpenes with dillapiol showed a synergistic antifungal effect with 1 and an additive effect with 4 and 5.

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Journal Journal of Natural Products
Amiguet, V.T. (Virginie Treyvaud), Petit, P. (Philippe), Ta, C.A. (Chieu Anh), Nuñez, R. (Ronaldo), Sánchez-Vindas, P. (Pablo), Alvarez, L.P. (Luis Poveda), … Durst, T. (Tony). (2006). Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. Journal of Natural Products, 69(7), 1005–1009. doi:10.1021/np0504863