In this study, 36 extracts derived from 29 plant species selected using an ethnobotanical approach were tested for antifungal activity against a taxonomically diverse group of 13 human pathogenic fungi. We compared the inhibitory characteristics of these plant extracts with those of the commonly used antifungals, amphotericin B and ketoconazole, and the plant-derived antifungal, berberine. Several plant extracts, notably those from Zingiber officinale (ginger) and Juglans cinerea (butternut), had pronounced antifungal activity against a wide variety of fungi, including strains that were highly resistant to amphotericin B and ketoconazole. Further exploration of Z. officinale as an antifungal is warranted as this species is generally regarded as safe for human consumption.

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Keywords Antifungal activity, Phytomedicine, Plants
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Journal Mycoses
Ficker, C.E. (Christine E.), Arnason, J.T. (J. T.), Vindas, P.S. (P. S.), Alvarez, L.P. (L. P.), Akpagana, K. (K.), Gbéassor, M. (M.), … Smith, M. (2003). Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses, 46(1-2), 29–37. doi:10.1046/j.1439-0507.2003.00838.x