A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 × higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy. Copyright

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Keywords African ginger, Antifungal, Gingerdiol, Gingerols, Human pathogenic fungi
Persistent URL dx.doi.org/10.1002/ptr.1335
Journal Phytotherapy Research
Ficker, C. (C.), Smith, M, Akpagana, K. (K.), Gbeassor, M. (M.), Zhang, J. (J.), Durst, T. (T.), … Arnason, J.T. (J. T.). (2003). Bioassay-guided isolation and identification of antifungal compounds from ginger. Phytotherapy Research, 17(8), 897–902. doi:10.1002/ptr.1335