Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4′-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4′-dihydroxyflavanone, 7-methoxy-3,5,4′-trihydroxyflavone, and 3,3′,4′,5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC50 values in the range of 1-3 μg/mL were found for compounds 3 and 5.

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Journal Journal of Natural Products
Kamnaing, P. (Pierre), Tsopmo, A, Tanifum, E.A. (Eric A.), Tchuendem, M.H.K. (Marguerite H. K.), Tane, P. (Pierre), Ayafor, J.F. (Johnson F.), … Bacchi, C. (Cyrus). (2003). Trypanocidal diarylheptanoids from Aframomum letestuianum. Journal of Natural Products, 66(3), 364–367. doi:10.1021/np020362f