A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1β,4β-diol, 1(10)E,5E-germacradien-4α-ol and eudesman-1,4,7-triol. A large amount of 5- hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquiterpenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.

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Keywords Antiplasmo dial activity, Eudesmane, Flavonoid, Germacrene, Isodaucane, Reneilmia cincinnata, Zingiberaceae
Persistent URL dx.doi.org/10.1016/S0031-9422(99)00344-1
Journal Phytochemistry
Tchuendem, M.H.K. (Maguerite H.K.), Mbah, J.A. (James A.), Tsopmo, A, Foyere Ayafor, J. (J.), Sterner, O. (Olov), Okunjic, C.C. (Christopher C.), … Schuster, B.M. (Brian M.). (1999). Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata. Phytochemistry, 52(6), 1095–1099. doi:10.1016/S0031-9422(99)00344-1