Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.

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Stress & Pathology Lab

Kent, P. (Pam), Bédard, T. (Tania), Khan, S. (Samir), Anisman, H, & Merali, Z. (Zul). (2001). Bombesin-induced HPA and sympathetic activation requires CRH receptors. Peptides, 22(1), 57–65. doi:10.1016/S0196-9781(00)00355-7