D- and L-nucleosides and analogues thereof, including the 4′-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.

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Persistent URL dx.doi.org/10.1021/ja905452f
Journal American Chemical Society Journal
Chapdelaine, D. (Daniel), Cardinal-David, B. (Benoit), Prévost, M. (Michel), Gagnon, M.A, Thumin, I. (Isabelle), & Guindon, Y. (Yvan). (2009). A stereoselective approach to nucleosides and 4′-thioanalogues from acyclic precursors. American Chemical Society Journal, 131(47), 17242–17245. doi:10.1021/ja905452f