In this double-blind study, the effects of diazepam (0.15 mg/kg intramuscularly for premedication and 0.3 mg/sec intravenously for induction) on memory were compared to those of standard premedication and induction agents, meperidine (1 mg/kg) and thiopentone (2.5 mg/sec). Forty patients (32 females and 8 males), in physical status I, undergoing minor elective operations, received an auditory stimulus immediately before induction of anaesthesia; stimulus recall as well as subjective side-effects were assessed the following day. The volunteers were randomly assigned to either of two groups, each receiving one of the premedicaments. The two groups were further subdivided into sub-groups corresponding to the induction agents and intubation. As a premedicant, diazepam produced more anterograde amnesia than meperidine without inducing any undesirable effect. Our results suggest that diazepam as an induction agent could possibly produce retrograde amnesia. The amnesic effects were more pronounced when diazepam was used successively for premedication and induction. Diazepam prevented the sore throat of intubation better than thiopentone, though it induced more nausea and vomiting.

Additional Metadata
Persistent URL dx.doi.org/10.1007/BF03005652
Journal Canadian Anaesthetists' Society Journal
Citation
Authier, L. (L.), Chapados, R. (R.), Sindon, A. (A.), & Gagnon, M.A. (1978). Amnesie et autres effets du diazepam dans la premedication et l'induction de l'anesthesie. Canadian Anaesthetists' Society Journal, 25(4), 297–302. doi:10.1007/BF03005652