It has now become apparent that a full understanding of a biological process (e.g. a disease state) is only possible if all biomolecular interactions are taken into account. Systems biology works towards understanding the intricacies of cellular life through the collaborative efforts of biologists, chemists, mathematicians and computer scientists and recently, a number of laboratories around the world have embarked upon such research agendas. The fields of genomics and proteomics are foundational in systems biology studies and a great deal of research is currently being conducted in each worldwide. Moreover, many technological advances (particularly in mass spectrometry) have led to a dramatic rise in the number of proteomic studies over the past two decades. This short review summarizes a selection of technological innovations in proteomics that contribute to systems biology studies.

Additional Metadata
Persistent URL dx.doi.org/10.1039/b606798k
Journal Molecular BioSystems
Citation
Smith, J. C, & Figeys, D. (Daniel). (2006). Proteomics technology in systems biology. Molecular BioSystems (Vol. 2, pp. 364–370). doi:10.1039/b606798k