This study examined factors that contributed to patient's eligibility and participation in a randomized controlled trial involving olanzapine for the adjunctive treatment of anorexia nervosa (AN). Factors involving patient eligibility and willingness to participate were systematically recorded for all patients approached to participate. Of the 92 patients that were assessed and treated over the study timeframe, only 27 patients (29%) met full criteria for inclusion, of which just 7 enrolled (26%). The most common reasons for study refusal related to fears associated with medication effects and refusal to consider medication as a treatment option (70%). Factors affecting recruitment in psychopharmacological studies involving AN in youth are discussed.

Additional Metadata
Persistent URL dx.doi.org/10.1080/10640261003719468
Journal Eating Disorders
Citation
Norris, M.L. (Mark L.), Spettigue, W. (Wendy), Buchholz, A. (Annick), Henderson, K, & Obeid, N. (Nicole). (2010). Factors influencing research drug trials in adolescents with anorexia nervosa. Eating Disorders, 18(3), 210–217. doi:10.1080/10640261003719468