Light-scattering simulations provide an efficient tool for studying cell morphology as well as the nature of scattering and its sources. The finite-difference time-domain (FDTD) method, based on the direct numerical solutions of time-dependent Maxwell's equations, helps in simulating light-scattering from single cells. The FDTD is effective because it enables modeling of a variety of light-propagation phenomena such as scattering, diffraction, reflection, refraction, absorption, and polarization effects. The method is extremely well suited for the design and analysis of submicron structures and devices with very fine structural basis.