The paper will focus on the discussion of recent unique examples of Finite-Difference Time-Domain (FDTD) simulations and modeling of biophotonics applications including Optical Phase Contrast Microscope (OPCM) imaging of cells containing gold nanoparticles (NPs). The discussion includes the case of OPCM microscopy as a prospective modality for in vivo flow cytometry. The application of the FDTD approach for the simulation of OPCM and flow cytometry imaging opens a new application area with a significant research potential.

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Keywords Biophotonics, Finite-difference time-domain method, Gold nanoparticles, Nanophotonics, Optical modeling, Optical phase contrast microscopy
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Conference 3rd International Workshop on Theoretical and Computational Nano-Photonics, TaCoNa-Photonics 2010
Tanev, S, Tuchin, V. (Valery), & Pond, J. (James). (2010). FDTD modeling of nano- and bio-photonic imaging. In AIP Conference Proceedings (pp. 30–34). doi:10.1063/1.3506119