In this invited paper we focus on the discussion of two recent unique applications of the Finite-Difference Time-Domain (FDTD) simulation method to the design and modeling of advanced nano- and bio-photonic problems. We will first discuss the application of a traditional formulation of the FDTD approach to the modeling of sub-wavelength photonics structures. Next, a modified total/scattered field FDTD approach will be applied to the modeling of biophotonics applications including Optical Phase Contrast Microscope (OPCM) imaging of cells containing gold nanoparticles (NPs) as well as its potential application as a modality for in vivo flow cytometry configurations. The discussion of the results shows that the specifics of optical wave phenomena at the nano-scale opens the opportunity for the FDTD approach to address new application areas with a significant research potential.

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Keywords Biological cell, Biomedical imaging, Finite-difference time-domain method, Gold nanoparticles, Optical clearing effect, Optical phase contrast microscope, Sub-wavelength nanophotonic structures
Persistent URL dx.doi.org/10.1117/12.881624
Conference 16th International School on Quantum Electronics: Laser Physics and Applications
Citation
Tanev, S, Tuchin, V. (Valery), Cheben, P. (Pavel), Bock, P. (Przemek), Schmid, J. (Jens), & Pond, J. (James). (2011). Advances in photonics design and modeling for nano- and bio-photonics applications. In Proceedings of SPIE - The International Society for Optical Engineering. doi:10.1117/12.881624