OBJECTIVE: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. APPROACH: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. MAIN RESULTS: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. SIGNIFICANCE: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.

Physiological Measurement
Department of Systems and Computer Engineering

Stowe, S. (Symon), Boyle, A. (Alistair), Sage, M. (Michaël), See, W. (Wendy), Praud, J.-P. (Jean-Paul), Fortin-Pellerin, É. (Étienne), & Adler, A. (2019). Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model. Physiological Measurement, 40(5). doi:10.1088/1361-6579/ab1794