Signal transduction pathways transmit information received at the cell surface to intracellular targets which direct a response. We highlight the involvement of signaling pathways in mediating transitions between mammalian torpor and euthermia and suggest these promote survival under stressors (e.g., hypothermia, ischemia-reperfusion) that would otherwise cause damage in nonhibernators.

arousal, entrance, mammalian hibernation, signal transduction, stress response
Department of Biology

Tessier, S.N. (Shannon N), & Storey, K. (2014). Transitioning between entry and exit from mammalian torpor: The involvement of signal transduction pathways. Temperature, 1(2), 92–93. doi:10.4161/temp.29972