Divining The Spliceosome The missing link between humanity's small genome and huge proteome reveals some secrets
Researchers are making efforts to find out the missing link between our small genome and huge proteome is the spliceosome, a massive protein-RNA hybrid machine that lurks in the nucleus of every human cell. The complicated catalyst slices and dices the messenger RNA transcribed from DNA into myriad different forms before translation into proteins by the ribosome, and the mRNA from 90% of humans' genes gets alternatively spliced. Every human mRNA has about three alternative splicing sites, but the mRNA from some human genes gets spliced into thousands of different arrangements, where the spliceosome is responsible for bequeathing humanity all its complexity. Several teams of electron microscopists have caught the spliceosome in action, although their images are far from having atomic resolution, to observe the hustle and bustle of spliceosome components in a live cell.
Everts, S. (2009). Divining The Spliceosome The missing link between humanity's small genome and huge proteome reveals some secrets. doi:10.1021/cen-v087n018.p046