Cyclin-dependent kinases (CDKs) are best characterized for their ability to control cell-cycle progression. However, CDK family members are now known to regulate biological processes outside of the cell cycle, including transcription and neuronal development. Multiple CDKs (both cell cycle and non-cell-cycle related) have been associated with neurological conditions, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This review will explore the emerging evidence supporting a role for CDKs in neuronal death, focusing on mechanisms involved in the dopaminergic neurodegeneration of PD. An improved understanding of CDK involvement in cell death signaling could facilitate the development of innovative strategies to halt or slow down the characteristic death processes that are associated with some neurodegenerative conditions.

Additional Metadata
Persistent URL dx.doi.org/10.1016/j.molmed.2004.07.003
Journal Trends in Molecular Medicine
Citation
Smith, P, O'Hare, M.J. (Michael J.), & Park, D.S. (David S.). (2004). CDKs: Taking on a role as mediators of dopaminergic loss in Parkinson's disease. Trends in Molecular Medicine (Vol. 10, pp. 445–451). doi:10.1016/j.molmed.2004.07.003