The interest in using non-invasive brain stimulation (NIBS) for the treatment of major depression (MD), including treatment resistant depression, is growing rapidly. The paper by Bennabi and Haffen (Brain Sci. 2018, 8) was an important step towards the formal acceptance of transcranial direct current stimulation (tDCS) as a possible form of therapy. Their review demonstrated favourable support for the beneficial effects of tDCS for MD, coupled with necessary practical considerations, such as its relatively low cost, portability/ease of use in clinical settings, non-invasiveness, and good tolerability. Here, we provide a follow-up to their review and sketch a current update. Means for optimizing tDCS efficacy and potential limitations of current studies are discussed.

Major depression, NIBS, Non-invasive brain stimulation, TDCS, Transcranial direct current stimulation, Transcranial magnetic stimulation, Transcranial magnetic stimulation (TMS)
dx.doi.org/10.3390/brainsci10080480
Brain Sciences
Department of Neuroscience

Buchanan, D.M. (Derrick Matthew), Robaey, P. (Philippe), & D'Angiulli, A. (2020). What do we know about transcranial direct current stimulation for major depression?. Brain Sciences, 10(8), 1–5. doi:10.3390/brainsci10080480