Fructose 2,6-bisphosphate is a potent activator of cockroach flight muscle 6-phosphofructo-1-kinase; at 5 μM, fructose 2,6-P2 lowers S0.5 for fructose 6-P 36-fold from 16 ± 0.90 to 0.44 ± 0.14 mM. Muscle concentration of fructose 2,6-P2 is elevated at the initiation of flight suggesting that the compound plays a key role in the activation of muscle phosphofructokinase, and therefore in the activation of glycolytic flux, during the initiation of flight.

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Keywords Activation of glycolysis, Fructose 2, 6-bisphosphate, Insect flight muscle, Phosphofructokinase
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Journal FEBS Letters
Storey, K. (1983). Regulation of cockroach flight muscle phosphofructokinase by fructose 2,6-bisphosphate. Role in the activation of muscle metabolism during flight. FEBS Letters, 161(2), 265–268. doi:10.1016/0014-5793(83)81022-9