Regulation of cockroach flight muscle phosphofructokinase by fructose 2,6-bisphosphate. Role in the activation of muscle metabolism during flight
FEBS Letters , Volume 161 - Issue 2 p. 265- 268
Fructose 2,6-bisphosphate is a potent activator of cockroach flight muscle 6-phosphofructo-1-kinase; at 5 μM, fructose 2,6-P2 lowers S0.5 for fructose 6-P 36-fold from 16 ± 0.90 to 0.44 ± 0.14 mM. Muscle concentration of fructose 2,6-P2 is elevated at the initiation of flight suggesting that the compound plays a key role in the activation of muscle phosphofructokinase, and therefore in the activation of glycolytic flux, during the initiation of flight.
|Activation of glycolysis, Fructose 2, 6-bisphosphate, Insect flight muscle, Phosphofructokinase|
|Organisation||Department of Biology|
Storey, K. (1983). Regulation of cockroach flight muscle phosphofructokinase by fructose 2,6-bisphosphate. Role in the activation of muscle metabolism during flight. FEBS Letters, 161(2), 265–268. doi:10.1016/0014-5793(83)81022-9