More accurate fitting of 125I and 103Pd radial dose functions
In this study an improved functional form for fitting the radial dose functions, g (r), of 125I and 103Pd brachytherapy seeds is presented. The new function is capable of accurately fitting radial dose functions over ranges as large as 0.05 cm≤r≤10 cm for 125I seeds and 0.10 cm≤r≤10 cm for 103Pd seeds. The average discrepancies between fit and calculated data are less than 0.5% over the full range of fit and maximum discrepancies are 2% or less. The fitting function is also capable of accounting for the sharp increase in g (r) (upturn) seen for some sources for r<0.1 cm. This upturn has previously been attributed to the breakdown of the approximation of the sources as a line, however, in this study we demonstrate that another contributing factor is the 4.5 keV characteristic x-rays emitted from the Ti seed casing. Radial dose functions are calculated for 18 125I seeds and 9 103Pd seeds using the EGSnrc Monte Carlo user-code BrachyDose. Fitting coefficients of the new function are tabulated for all 27 seeds. Extrapolation characteristics of the function are also investigated. The new functional form is an improvement over currently used fitting functions with its main strength being the ability to accurately fit the rapidly varying radial dose function at small distances. The new function is an excellent candidate for fitting the radial dose function of all 103Pd and 125I brachytherapy seeds and will increase the accuracy of dose distributions calculated around brachytherapy seeds using the TG-43 protocol over a wider range of data. More accurate values of g (r) for r<0.5 cm may be particularly important in the treatment of ocular melanoma.
|Keywords||EGSnrc, Functional fit, g(r), I-125, LDR brachytherapy, Monte Carlo, Pd-103, Radial dose function|
Taylor, R.E.P., & Rogers, D.W.O. (2008). More accurate fitting of 125I and 103Pd radial dose functions. Medical Physics, 35(9), 4242–4250. doi:10.1118/1.2964097