Chemical constituents from the bark of Anisopus mannii

A minor novel 1,7-naphthyridine alkaloid with an unprecedented skeleton, named anisopusine (1), was isolated from the CH 2Cl 2 soluble materials of an acetone extract of the bark of Anisopus mannii (Asclepiadaceae) together with four known compounds 5α-hydroxy-lup-20(29)- en-3β-yl eicosanoate (2), [6]-gingerdione (3), [6]-dehydrogingerdione (4), and ferulic acid (5). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR, HREI-MS. Compounds (2-5) were characterized for the first time from this genus.

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