Preliminary studies of an 18-crown-6 ether modified magnetic cation exchange polymer in rapid 90Sr bioassay
A cation exchange polymer resin embedded with magnetic nanoparticles and modified with crown ether was developed for urinalysis to rapidly monitor levels of 90Sr exposure in humans who have been involved in a nuclear event. Invention of the resin matrix of 2-acrylamido-2-methyl-1-propanesulfonic acid cross-linked with divinylbenzene incorporated a Sr2+ chelating agent, di-tert-butyl-cyclohexano-18-crown-6 through surface immobilization using a molecular modifier 1-octanol. The performance of these magnetic cation exchange resin particles was investigated by separating 90Sr in the presence of 90Y progeny. Masking agents and precipitants were examined to ascertain that sodium hydroxide at pH 7.5 was capable of selectively removing 89 ± 2% 90Y before subsequent 90Sr uptake. Preliminary investigations in rapid urinalysis were successful in isolating 83 ± 2% 90Sr when pH was optimized to 9, with a sample turnover time <2 h, which is promising for radiological emergencies.
|Keywords||90Sr, 90Y, bioassay, radiation protection|
Hrdina, A. (Amy), Lai, E. P, Li, C. (Chunsheng), Sadi, B. (Baki), & Kramer, G. (Gary). (2011). Preliminary studies of an 18-crown-6 ether modified magnetic cation exchange polymer in rapid 90Sr bioassay. Health Physics, 101(2), 187–195. doi:10.1097/HP.0b013e318217fbe3