The metal ion binding characteristics of molecularly imprinted polymer (MIP) submicron particles prepared using 17β-estradiol (E2) as a template, and incorporated with dicyclohexano-18-crown-6 (DCH18C6), were studied using differential pulse anodic stripping voltammetry. When Sr2+ was added to DCH18C6-E2-MIP particles already occupied by Cd2+, Cu 2+, and Pb2+ inside the binding sites, a displacement reaction was observed: Cd2+/Cu2+/Pb2+-DCH18C6- E2-MIP + Sr2+ = Sr2+-DCH18C6-E2-MIP + Cd 2+/Cu2+/Pb2+. This demonstrated that DCH18C6 had stronger binding affinity for Sr2+ than Cd2+ Cu 2+ or Pb2+. Strong DCH18C6 binding affinity was also observed for Y3+. Atomic emission spectrometry showed that DCH18C6-E2-MIP particles (150 mg/mL) resulted in 52% binding of Sr2+ (2000 ppm, at pH 6.3 ± 0.1 and ionic strength of 0.1M NaNO2).

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Keywords 17β-estradiol, atomic emission spectrometry, dicyclohexano-18-crown-6, differential pulse anodic stripping voltammetry, molecularly imprinted polymer, strontium, submicron particles
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Journal Journal of Applied Polymer Science
Lai, E. P, Bahraini, N. (Negar), Li, C. (Chunsheng), Sadi, B.B. (Baki B.), & Kramer, G.H. (Gary H.). (2012). Cd2+, Cu2+, Pb2+, Sr2+, and Y3+ binding characteristics of 17β-estradiol molecularly imprinted polymer particles incorporated with dicyclohexano-18-crown-6 for urine bioassay. Journal of Applied Polymer Science, 123(1), 12–19. doi:10.1002/app.34409