High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index (RI) perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the relationship between the intracellular density of cells (S50 and S60) and their RIs, the experimental results provide a potential way to verify the hypothesis for "density alteration in non-physiological cells (DANCE)".

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Keywords biosensor, refractometer, tilted fiber grating
Persistent URL dx.doi.org/10.1007/s11434-013-5724-3
Journal Chinese Science Bulletin , Natural Sciences and Engineering Research Council of Canada
Liu, F. (Fu), Guo, T, Liu, J.G. (JianGuo), Zhu, X.Y. (XiaoYang), Liu, Y. (Yu), Guan, B.O. (BaiOu), & Albert, J. (2013). High-sensitive and temperature-self-calibrated tilted fiber grating biological sensing probe. Natural Sciences and Engineering Research Council of Canada, 58(21), 2611–2615. doi:10.1007/s11434-013-5724-3