The effects of scopolamine (2.0 mg/kg) and d-amphetamine (3.0 mg/kg) on one-way, shuttle and inhibitory avoidance performance were evaluated in 3 strains of mice (A/J, DBA/2J and C57BL/6J) and their 6 reciprocal F1 hybrids. In the saline condition, intermediate inheritance was observed in the inhibitory task, complete dominance for superior avoidance in the one-way task, and hybrid superiority in the shuttle situation. Administration of d-amphetamine disrupted inhibitory performance in all strains. In the shuttle task no amphetamine effect was observed in C57BL/6J mice, while improvement was seen in A/J and DBA/2J mice, as well as in all the hybrid crosses. No drug effect was seen in the one-way task. As with d-amphetamine, scopolamine disrupted performance in the inhibitory task among the inbreds, but had negligible effects in the hybrids. In the shuttle task, only the A/J mice exhibited improved performance, while a small decline in response rate was seen in one-way avoidance. Results were interpreted in terms of the role of scopolamine and d-amphetamine in modifying non-associative factors involved in avoidance, and the interaction between associative and non-associative factors in modulating avoidance response rate.

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Keywords d-Amphetamine, Diallel analysis, Inhibitory avoidance, One-way avoidance, Scopolamine, Shuttle avoidance
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Journal Pharmacology, Biochemistry and Behavior
Anisman, H. (1975). Effects of scopolamine and d-amphetamine on one-way, shuttle and inhibitory avoidance: A diallel analysis in mice. Pharmacology, Biochemistry and Behavior, 3(6), 1037–1042. doi:10.1016/0091-3057(75)90013-1