High sensitivity biological sample measurements have been achieved by using a 12o tilted fiber Bragg grating (TFBG). Human acute leukemia cells with different intracellular densities and refractive index (RI) ranging from 1.3342 to 1.3344 were clearly discriminated in-situ by using the differential transmission spectrum between two orthogonal polarizations for the last guided mode resonance before "cut-off", with an amplitude variation sensitivity of 1.8×104 dB/RIU and a limit of detection of 2×10-5RIU. The technique is inherently temperature-insensitive.

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Keywords Density alteration in non-physiological cells, Optical biosensor, Optical fiber, Polarimetric fiber grating
Persistent URL dx.doi.org/10.1117/12.2058465
Conference 23rd International Conference on Optical Fibre Sensors
Guo, T, Liu, F. (Fu), Liu, Y. (Yu), Chen, N.-K. (Nan-Kuang), Guan, B.-O. (Bai-Ou), & Albert, J. (2014). Polarimetric fiber grating biosensor for in-situ high-sensitive intracellular density measurement. Presented at the 23rd International Conference on Optical Fibre Sensors. doi:10.1117/12.2058465