Three strains of mice were trained in a shuttle avoidance task following treatment with scopolamine (2.0 mg/kg) or d-amphetamine (3.0 mg/kg). When required to run towards light (CS) to avoid shock, A/J mice acquired the response more readily than DBA/2J or C57BL/6J mice. However, when required to run away from the light, the strain differences were eliminated. Under both testing conditions scopolamine and d-amphetamine augmented the performance of A/J mice, but had no effect or even disrupted performance of C57BL/6J. In DBA/2J mice d-amphetamine augmented performance only in the toward condition. Results were interpreted to support the hypothesis that scopolamine and d-amphetamine improve performance by response disinhibition and response excitation, respectively. The presence of associative difficulties limit the effects of these agents.

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Keywords Avoidance, d-amphetamine, Scopolamine, Stimulus factors, Strain differences
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Journal Pharmacology, Biochemistry and Behavior
Anisman, H. (1976). Role of stimulus locale on strain differences in active avoidance after scopolamine or D-Amphetamine treatment. Pharmacology, Biochemistry and Behavior, 4(1), 103–106. doi:10.1016/0091-3057(76)90182-9