Systemic treatment with d-amphetamine produced a dose-dependent increase in the circling behavior of normal mice. Treatment with both α-methyl-p-tyrosine (α-MpT) and FLA-63 antagonized the amphetamine-induced circling behavior. Similarly, blockade of B-adrenergic receptors by propranolol and dopamine receptors by haloperidol reversed the circling response elicited by amphetamine. In contrast to α-MpT and haloperidol, however, neither FLA-63 nor propranolol attenuated the locomotor excitation engendered by amphetamine. Following repeated d-amphetamine injections the circling ordinarily induced by a single injection was abolished, whereas the locomotor effects of amphetamine remained unaltered. These findings are consistent with earlier work suggesting that tolerance may occur in those behaviors that involve a noradrenergic component.

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Keywords α-Methyl-p-tyrosine, Circling behavior, d-Amphetamine, FLA-63, Haloperidol, Perseveration, Phenoxybenzamine, Propranolol, Tolerance
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Journal Psychopharmacologia
Kokkinidis, L. (Larry), & Anisman, H. (1979). Circling behavior following systemic d-amphetamine administration: Potential noradrenergic and dopaminergic involvement. Psychopharmacologia, 64(1), 45–54. doi:10.1007/BF00427344