Ontogenetic variation in amphetamine-induced stimulus perseveration was evaluated in a spontaneous alternation task. Swiss-Webster mice 15-20 days of age exhibited chance-level alternation, whereas 25-30-day-old mice exhibited alternation which exceeded chance. While scopolamine reduced alternation to chance levels, treatment with d-amphetamine produced marked perseverative behavior (i.e., below chance-level alternation). Among 15-day-old animals a lower dose of amphetamine was sufficient to elicit the perseveration. Apparatus preexposure enhanced perseveration among 25- to 30-day-old animals and produced minimal effects among 15- to 20-day-old mice. These results were discussed in terms of the involvement of cholinergic mechanisms in modifying the amphetamine-induced perseveration, as well as developmental factors which determine the perseverative response.

Behavioral and Neural Biology
Department of Psychology

Kokkinidis, L. (Larry), Irwin, J. (Jill), & Anisman, H. (1979). Ontogenetic variations in amphetamine-induced stimulus perseveration. Behavioral and Neural Biology, 26(2), 221–233. doi:10.1016/S0163-1047(79)92627-X