Wood frogs survive extracellular freezing at moderate subzero temperatures (-4°C) for at least 11 days. Freezing survival is aided by the accumulation of high concentrations of glucose as a cryoprotectant in blood and tissues. Glucose production was accompanied by a rapid decline in liver, but not muscle, glycogen levels suggesting that liver is the organ controlling cryoprotectant synthesis.

Additional Metadata
Keywords cryoprotectant synthesis, frog, freeze tolerance, glucose levels, cryoprotectant, glycogen levels, liver, Rana sylvatica
Persistent URL dx.doi.org/10.1007/BF01946664
Journal Experientia
Storey, K. (1984). Freeze tolerance in the frog, Rana sylvatica. Experientia, 40(11), 1261–1262. doi:10.1007/BF01946664