Most de novo microRNA prediction tools rely on RNA structure prediction as a pre-screening step - only those sequences that exhibit miRNA-like hairpin structures are considered as putative miRNAs. However, little attention has been paid to the quality of this pre-screening step. This prescreening may unduly limit the sensitivity of the miRNA prediction method. We here demonstrate that leveraging recent advances in RNA structure prediction results in significant increases in overall miRNA prediction recall and precision.

Additional Metadata
Keywords Free energy calculation, MicroRNA prediction, RNA structure prediction
Persistent URL dx.doi.org/10.1007/978-3-319-19387-8_359
Conference World Congress on Medical Physics and Biomedical Engineering, 2015
Citation
Peace, R.J., & Green, J. (2015). Updated free energy parameters increase microRNA prediction performance. Presented at the World Congress on Medical Physics and Biomedical Engineering, 2015. doi:10.1007/978-3-319-19387-8_359