Exposure to acute inescapable footshock provoked marked increases of plasma corticosterone concentrations in six strains of mice (A/J, Balb/cByJ, C57BL/6J, C3H/HeJ, DBA/2J and CD-1). However, the magnitude of the increase, as well as the time required for corticosterone to return to control values, varied appreciably across strains. Moreover, it appeared that the strain-specific corticoid increases ordinarily observed after acute shock were also evident following a chronic stressor regimen. The data were related to previously observed strain differences in stressor-induced alterations of brain norepinephrine, dopamine and serotonin, as well as variations in performance in several behavioral paradigms.

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Pharmacology, Biochemistry and Behavior
Department of Psychology

Shanks, N. (Nola), Griffiths, J. (Jenna), Zalcman, S. (Steve), Zacharko, R.M. (Robert M.), & Anisman, H. (1990). Mouse strain differences in plasma corticosterone following uncontrollable footshock. Pharmacology, Biochemistry and Behavior, 36(3), 515–519. doi:10.1016/0091-3057(90)90249-H