Exposure to acute inescapable footshock provoked marked increases of plasma corticosterone concentrations in six strains of mice (A/J, Balb/cByJ, C57BL/6J, C3H/HeJ, DBA/2J and CD-1). However, the magnitude of the increase, as well as the time required for corticosterone to return to control values, varied appreciably across strains. Moreover, it appeared that the strain-specific corticoid increases ordinarily observed after acute shock were also evident following a chronic stressor regimen. The data were related to previously observed strain differences in stressor-induced alterations of brain norepinephrine, dopamine and serotonin, as well as variations in performance in several behavioral paradigms.

Corticosterone, Strain differences, Stress
Pharmacology, Biochemistry and Behavior
Department of Psychology

Shanks, N. (Nola), Griffiths, J. (Jenna), Zalcman, S. (Steve), Zacharko, R.M. (Robert M.), & Anisman, H. (1990). Mouse strain differences in plasma corticosterone following uncontrollable footshock. Pharmacology, Biochemistry and Behavior, 36(3), 515–519. doi:10.1016/0091-3057(90)90249-H